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When the identified etiology of acute pericarditis is not viral or idiopathic, management should be directed toward treating the underlying cause.
Oral doses of up to 400mg Gynostemma Pentaphyllum for 2 months has been shown to be safe in otherwise healthy humans.
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Long-Term Efficacy of Interleukin-1 Receptor Antagonist (Anakinra) in Corticosteroid-Dependent and Colchicine-Resistant Recurrent Pericarditis.
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Alcohol can decrease this drug's effectiveness.
The colchicines has well-established anti-inflammatory effects on neutrophills.
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Spot urine uric acid to creatinine ratio used in the estimation of uric acid excretion in primary gout.
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Specifically, the FDA would grant three years of marketing exclusivity to the first company to receive a formal approval, or seven years if the drug was for an orphan disease.
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Colchicine is an ancient medication that has been used in the treatment of other inflammatory diseases such as gout.
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Update on mechanisms of action and therapeutic uses.
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Two-dimensional echocardiography, cardiac CT, or CMR may be used to differentiate pericardial cysts from other solid tumors.
These differences have no effect on the medical action of the drug whatsoever.
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CoQ10 may be altered during the aging process, as the REDOX ratio of ubiquinone (oxidized form) to ubiquinol (reduced form) has been noted to be increased during aging.
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Suppression of microtubule dynamics by tubulin mutations or by drug treatment have been shown to inhibit cell migration.
Cases of acute liver injury attributed to colchicine overdose have been self-limited, and the other toxicities of this agent generally overshadowed the hepatic injury.
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No additional ritonavir is recommended when saquinavir is administered with lopinavir 400 mg-ritonavir 100 mg twice a day.
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Urinary clearance of colchicine and its metabolites may be decreased in patients with impaired renal function.
Avoid eating grapefruit or drinking grapefruit juice while taking Colchicine Tablets, USP.
However, it is not beneficial when given during the occurrence of an acute episode of FMF.
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The administration of Fab fragments increased the total plasma colchicine concentration by a factor of 6 (from 12 to 70 ng per milliliter) 10 minutes after the start of the infusion ( Figure 1 Concentrations of Colchicine in the Plasma and Urine of the Study Patient.
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Colchicine has been reported to adversely affect spermatogenesis in animals.
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Dosage adjustment for concomitant therapy with CYP3A4 or P-glycoprotein (P-gp) inhibitors: Note: Colcrys labeling recommends dosage adjustments in patients receiving CYP3A4 or P-gp inhibitors up to 14 days prior to initiation of colchicine.
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